Title : Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin.

Pub. Date : 2004 Nov 15

PMID : 14764524






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PF4 binds to heparin with high affinity, but its in vivo biologic role has not been defined. Heparin platelet factor 4 Mus musculus
2 The thrombotic defect in the mPF4(+/-) and mPF4(-/-) animals was particularly sensitive to infusions of the negatively charged anticoagulant heparin. Heparin platelet factor 4 Mus musculus
3 The thrombotic defect in the mPF4(+/-) and mPF4(-/-) animals was particularly sensitive to infusions of the negatively charged anticoagulant heparin. Heparin platelet factor 4 Mus musculus