Title : Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia.

Pub. Date : 2004 Feb

PMID : 14755730






5 Functional Relationships(s)
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1 Exposure of cultured neurons to the neurotoxic HIV proteins gp120 and Tat resulted in increased cellular levels of sphingomyelin, ceramide, and HNE. Ceramides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
2 The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death. Ceramides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
3 The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death. Ceramides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
4 The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death. Ceramides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
5 The ceramide precursor palmitoyl-CoA sensitized neurons to Tat and gp120 toxicity, whereas an inhibitor of ceramide production reduced Tat and gp120-induced increases of ceramide and HNE and protected the neurons from Tat and gp120-induced death. Ceramides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens