Pub. Date : 2004 Mar
PMID : 14747882
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
2 | BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
3 | BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
4 | BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
5 | BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
6 | RESULTS: The urinary NAT2 ratios (AFMU+AAMU) / (AFMU+AAMU+1X+1U) before and after caffeine intake correlated well in 65 volunteers (r(2)=0.827; P< 0.0001). | Caffeine | N-acetyltransferase 2 | Homo sapiens |
7 | CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS. | Caffeine | N-acetyltransferase 2 | Homo sapiens |
8 | CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS. | Caffeine | N-acetyltransferase 2 | Homo sapiens |