Title : Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.

Pub. Date : 2004 Mar

PMID : 14747882






8 Functional Relationships(s)
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1 Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. Caffeine N-acetyltransferase 2 Homo sapiens
2 BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. Caffeine N-acetyltransferase 2 Homo sapiens
3 BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. Caffeine N-acetyltransferase 2 Homo sapiens
4 BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. Caffeine N-acetyltransferase 2 Homo sapiens
5 BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. Caffeine N-acetyltransferase 2 Homo sapiens
6 RESULTS: The urinary NAT2 ratios (AFMU+AAMU) / (AFMU+AAMU+1X+1U) before and after caffeine intake correlated well in 65 volunteers (r(2)=0.827; P< 0.0001). Caffeine N-acetyltransferase 2 Homo sapiens
7 CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS. Caffeine N-acetyltransferase 2 Homo sapiens
8 CONCLUSION: NAT2 activity can be determined from a spontaneous urine probe in most subjects by quantification of caffeine metabolites arising from non-standardized dietary caffeine exposure using LC-MS/MS. Caffeine N-acetyltransferase 2 Homo sapiens