Title : Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases.

Pub. Date : 2004 Feb 12

PMID : 14746879






2 Functional Relationships(s)
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1 Western blot analysis showed that expression of COX-2 and iNOS, but not COX-1, decreased significantly in the spinal cords of salicylate-treated rats compared with vehicle-treated controls (P<0.05) and this finding was paralleled by immunohistochemical observations. Salicylates nitric oxide synthase 2 Rattus norvegicus
2 These results suggest that the amelioration by salicylate of paralysis in rats with EAE is mediated in part by the suppression of COX and iNOS. Salicylates nitric oxide synthase 2 Rattus norvegicus