Pub. Date : 2004 Jan 30
PMID : 14732465
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Postsynaptic density protein 95 mediates Ca2+/calmodulin-dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 2 | Recent study has indicated that postsynaptic density protein 95 (PSD95) promotes Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated serine phosphorylation of neuronal nitric oxide synthase (nNOS). | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 3 | Recent study has indicated that postsynaptic density protein 95 (PSD95) promotes Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated serine phosphorylation of neuronal nitric oxide synthase (nNOS). | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 4 | To investigate whether PSD95 is involved in the brain ischemia-induced enhancement of serine phosphorylation of nNOS by CaMKII in rat hippocampus, we examined the interactions among CaMKIIalpha, PSD95 and nNOS, and the effects of suppression of PSD95 expression on both the increased serine phosphorylation of nNOS and the interactions mentioned above by immunoprecipitation and immunoblotting. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 5 | (2) Intracerebroventricular infusion of PSD95 antisense oligodeoxynucleotides, but not missense oligodeoxynucleotides or vehicle, not only significantly decreased the protein level of PSD95 but also attenuated the elevated serine phosphorylation of nNOS and the interactions among CaMKIIalpha, PSD95 and nNOS induced by 15 min ischemia. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 6 | (2) Intracerebroventricular infusion of PSD95 antisense oligodeoxynucleotides, but not missense oligodeoxynucleotides or vehicle, not only significantly decreased the protein level of PSD95 but also attenuated the elevated serine phosphorylation of nNOS and the interactions among CaMKIIalpha, PSD95 and nNOS induced by 15 min ischemia. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 7 | (2) Intracerebroventricular infusion of PSD95 antisense oligodeoxynucleotides, but not missense oligodeoxynucleotides or vehicle, not only significantly decreased the protein level of PSD95 but also attenuated the elevated serine phosphorylation of nNOS and the interactions among CaMKIIalpha, PSD95 and nNOS induced by 15 min ischemia. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |
| 8 | These data suggested that PSD95 is important for facilitating nNOS serine phosphorylation by CaMKII. | Serine | discs large MAGUK scaffold protein 4 | Rattus norvegicus |