Title : HIF-1: an oxygen and metal responsive transcription factor.

Pub. Date : 2004 Jan

PMID : 14726713






1 Functional Relationships(s)
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1 Iron is central to the oxygen sensing mechanism, and sensitivity to other metals, namely cobalt and nickel, is a distinctive feature of the HIF system; in fact, this is often used as an initial way of implicating HIF-1 in a biological response. Cobalt hypoxia inducible factor 1 subunit alpha Homo sapiens