Title : Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.

Pub. Date : 2004 Jan

PMID : 14718923






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Crystal structures of nNOS-selective dipeptide inhibitors in complex with both nNOS and eNOS were solved and the inhibitors were found to adopt a curled conformation in nNOS but an extended conformation in eNOS. Dipeptides nitric oxide synthase 1 Homo sapiens
2 Crystal structures of nNOS-selective dipeptide inhibitors in complex with both nNOS and eNOS were solved and the inhibitors were found to adopt a curled conformation in nNOS but an extended conformation in eNOS. Dipeptides nitric oxide synthase 1 Homo sapiens
3 Crystal structures of nNOS-selective dipeptide inhibitors in complex with both nNOS and eNOS were solved and the inhibitors were found to adopt a curled conformation in nNOS but an extended conformation in eNOS. Dipeptides nitric oxide synthase 1 Homo sapiens
4 Therefore, a single-residue difference is responsible for more than two orders of magnitude selectivity in inhibition of nNOS over eNOS by L-N(omega)-nitroarginine-containing dipeptide inhibitors. Dipeptides nitric oxide synthase 1 Homo sapiens