Title : Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes.

Pub. Date : 2004 Feb

PMID : 14717847






5 Functional Relationships(s)
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1 Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes. Quercetin tyrosinase Homo sapiens
2 As compared with controls, melanin content was increased about sevenfold by treatment with 20 microM (HMVII) or 1 microM (NHEM) quercetin for 7 d. Tyrosinase activity was also increased, to 61.8-fold higher than the control. Quercetin tyrosinase Homo sapiens
3 The expression of tyrosinase protein was slightly increased by the addition of quercetin. Quercetin tyrosinase Homo sapiens
4 Tyrosinase activation by quercetin was blocked by actinomycin-D or by cycloheximide demonstrating that its actions in stimulating melanogenesis may involve both transcriptional and translational events. Quercetin tyrosinase Homo sapiens
5 Taken together, these results demonstrate that in human melanoma cells and in NHEM, quercetin stimulates melanogenesis by increasing tyrosinase activity and decreasing other factors such as melanogenic inhibitors. Quercetin tyrosinase Homo sapiens