Title : Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia.

Pub. Date : 2004 Jan 7

PMID : 14715932






1 Functional Relationships(s)
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1 The ATP-provoked activation of JNK and p38 [but not extracellular signal-regulated kinase (ERK)] could be inhibited by brilliant blue G, a P2X7 receptor blocker, and by genistein and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, which are general and src-family-specific tyrosine kinase inhibitors, respectively. Genistein mitogen-activated protein kinase 8 Homo sapiens