Title : Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia: role of HIF-1.

Pub. Date : 2004 Jan 30

PMID : 14715242






3 Functional Relationships(s)
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Protein Name
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1 Regardless of the oxygen concentration, 15d-PGJ(2) inhibited activity of hypoxia inducible factor-1 (HIF-1), the major hypoxic regulator of VEGF. 15d-pgj hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Regardless of the oxygen concentration, 15d-PGJ(2) inhibited activity of hypoxia inducible factor-1 (HIF-1), the major hypoxic regulator of VEGF. 15d-pgj hypoxia inducible factor 1 subunit alpha Homo sapiens
3 In hypoxia, however, the stimulatory effect of HO-1 is outweighed by 15d-PGJ(2)-mediated inhibition of the HIF-1 pathway. 15d-pgj hypoxia inducible factor 1 subunit alpha Homo sapiens