Title : Conjugated linoleic acid upregulates LDL receptor gene expression in HepG2 cells.

Pub. Date : 2004 Jan

PMID : 14704295






2 Functional Relationships(s)
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1 Incubation of HepG2 cells in serum-free medium supplemented with 25-hydroxycholesterol (25OH, 5 mg/L) for 24 h decreased LDLr protein and mRNA by 50-70% (P<0.05) and mature SREBP-1 by 20-40% (P<0.05). 25-hydroxycholesterol sterol regulatory element binding transcription factor 1 Homo sapiens
2 Incubation of HepG2 cells in serum-free medium supplemented with 25-hydroxycholesterol (25OH, 5 mg/L) for 24 h decreased LDLr protein and mRNA by 50-70% (P<0.05) and mature SREBP-1 by 20-40% (P<0.05). 25-hydroxycholesterol sterol regulatory element binding transcription factor 1 Homo sapiens