Title : Inhibition of epidermal growth factor receptor expression by RNA interference in A549 cells.

Pub. Date : 2004 Jan

PMID : 14704124






2 Functional Relationships(s)
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1 Compared with the control group, dsRNA-EGFR reduced the cell number by 85.0 %, decreased the colonies by 63.3 %, inhibited the migration by 87.2 %, and increased the sensitivity of A549 to cisplatin by four-fold. Cisplatin epidermal growth factor receptor Homo sapiens
2 CONCLUSION: Sequence specific dsRNA-EGFR were capable of suppressing EGF receptor expression, hence significantly inhibiting cellular proliferation and motility, and enhancing chemosensitivity of A549 cells to cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens