Title : Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.

Pub. Date : 2004 Mar 19

PMID : 14699155






1 Functional Relationships(s)
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1 Inhibition of Syk with piceatannol or PI3K with wortmannin inhibited LPS-induced JNK activation and decreased MCP-1 expression after exposure to LPS, suggesting that both Syk and PI3K reside in a signaling pathway leading to LPS-induced JNK activation in neutrophils. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens