Title : CHFR-associated early G2/M checkpoint defects in breast cancer cells.

Pub. Date : 2004 Jan

PMID : 14694445






3 Functional Relationships(s)
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1 Eleven of these 12 (92%) low-CHFR-expressing cell lines had an unusually high number of condensed chromosomes and high mitotic indices in response to nocodazole treatment. Nocodazole checkpoint with forkhead and ring finger domains Homo sapiens
2 Transfection of CHFR in one of these cancer cell lines lowered the mitotic index after nocodazole treatment. Nocodazole checkpoint with forkhead and ring finger domains Homo sapiens
3 In conclusion, our data suggested that low CHFR expression associated with high mitotic indices in response to nocodazole treatment were common in the breast cancer cell lines studied. Nocodazole checkpoint with forkhead and ring finger domains Homo sapiens