Protein Name checkpoint with forkhead and ring finger domains
Organism Homo sapiens
Gene ID 55743
Gene Symbol

CHFR

UniProt Q96EP1 (CHFR_HUMAN)
Relationships Total Number of functionally related compound(s) : 27
Total Number of Articles : 53
Description

checkpoint with forkhead and ring finger domains

Gene Summary

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

synonyms
  • E3 ubiquitin-protein ligase CHFR
  • RING finger protein 196
  • RING-type E3 ubiquitin transferase CHFR
Click to show/hide the synonyms
Properties