Pub. Date : 2004 Jan
PMID : 14694442
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. | 2-Methoxyestradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. | 2-Methoxyestradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. | 2-Methoxyestradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Moreover, we found that inhibition of 2-ME-induced extracellular signal-regulated kinase (ERK) activation by the upstream kinase inhibitor PD98059 significantly enhanced 2-ME-mediated suppression of Akt activation, resulting in much greater sensitization to apoptosis. | 2-Methoxyestradiol | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Taken together, the present findings indicate that 2-ME suppresses NF-kappaB/FLIP signaling and enhances DISC formation through inhibition of Akt, and that PC3 cells thereby are being sensitized to Fas-mediated apoptosis and by a process closely associated with ERK. | 2-Methoxyestradiol | mitogen-activated protein kinase 1 | Homo sapiens |