Title : The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2.

Pub. Date : 2003 Dec

PMID : 14671431






1 Functional Relationships(s)
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1 However, cisplatin, 5-FU and cyclophosphamide are not P-gp substrates, yet cisplatin, 5-FU and possibly cyclophosphamide are purported substrates for multidrug resistance proteins (MRPs) 1 and 2 (known to cause chemotherapy resistance). Cisplatin ATP binding cassette subfamily B member 1 Homo sapiens