Pub. Date : 2003 Sep-Oct
PMID : 14666688
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inositol hexaphosphate inhibits constitutive activation of NF- kappa B in androgen-independent human prostate carcinoma DU145 cells. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Since transcription factor NF-kappa B is constitutively active in advanced and androgen-independent human PCA DU145 cells, here we assessed whether IP6 inhibits this constitutively active NF-kappa B and associated upstream effectors and whether such an affect of IP6 has biological relevance in causing inhibition of proliferation and induction of apoptosis in DU145 cells. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | RESULTS: Treatment of cells with 1 and 2 mM doses of IP6 resulted in a strong inhibition of NF-kappa B activation, which was consistent with a decrease in nuclear levels of NF-kappa B sub-unit proteins p65 and p50. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | CONCLUSION: Our results suggest that IP6 could be a potent dietary agent in controlling the growth of advanced PCA cells and inducing their apoptotic death, in part, by its inhibitory effect on constitutively active NF-kappa B signaling pathway. | Phytic Acid | nuclear factor kappa B subunit 1 | Homo sapiens |