Title : Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis.

Pub. Date : 2004 Feb 27

PMID : 14662772






2 Functional Relationships(s)
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1 Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi complex (Lala, P., Ito, S., and Lingwood, C. A. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens
2 Microsomal lactosyl ceramide and globotriaosyl ceramide synthesis from endogenous or exogenously added liposomal glucosyl ceramide was inhibited by cyclosporin A, consistent with a direct role for MDR1/glucosyl ceramide translocase activity in their synthesis. Glucosylceramides ATP binding cassette subfamily B member 1 Homo sapiens