Title : The Mre11 complex is required for ATM activation and the G2/M checkpoint.

Pub. Date : 2003 Dec 15

PMID : 14657032






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 It is unclear which proteins recognize DSBs and activate these pathways, but the Mre11/Rad50/NBS1 complex has been suggested to act as a damage sensor. dsbs MRE11 homolog, double strand break repair nuclease Homo sapiens
2 Using these viral proteins, we show that the Mre11 complex is required for both ATM activation and the ATM-dependent G(2)/M checkpoint in response to DSBs. dsbs MRE11 homolog, double strand break repair nuclease Homo sapiens