Pub. Date : 2003 Dec 26
PMID : 14651966
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 2 | Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 3 | Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 4 | Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 5 | Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 6 | Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells. | Reactive Oxygen Species | plasminogen | Mus musculus |
| 7 | These results suggest that plasminogen activates microglia via stimulation of ROS production. | Reactive Oxygen Species | plasminogen | Mus musculus |