Pub. Date : 2003 Dec 15
PMID : 14637189
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined the effect of indirubin in MCF-7 breast cancer cells on induction of the activities of cytochromes P450 (CYP) 1A1 and 1B1, as measured by estradiol and ethoxyresorufin metabolism, and on induction of the CYP1A1 and CYP1B1 mRNAs. | indirubin | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | We determined the effect of indirubin in MCF-7 breast cancer cells on induction of the activities of cytochromes P450 (CYP) 1A1 and 1B1, as measured by estradiol and ethoxyresorufin metabolism, and on induction of the CYP1A1 and CYP1B1 mRNAs. | indirubin | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Indirubin was metabolized by microsomes containing cDNA-expressed human CYP1A1 or CYP1B1. | indirubin | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Thus, if indirubin is an endogenous AhR ligand, then AhR-mediated signaling by indirubin is likely to be transient and tightly controlled by the ability of indirubin to induce CYP1A1 and CYP1B1, and hence its own metabolism. | indirubin | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |