Title : Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

Pub. Date : 2004 Jan

PMID : 14628297






1 Functional Relationships(s)
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1 When stereoselective metabolism of racemic methadone by CYP2B6, 2C19, and 3A4 was examined using an enantiospecific methadone assay, CYP2B6 preferentially metabolized (S)-methadone, CYP2C19 preferentially metabolized (R)-methadone, and CYP3A4 showed no preference. Methadone cytochrome P450 family 2 subfamily C member 19 Homo sapiens