Pub. Date : 2003 Nov
PMID : 14625694
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells. | conophylline | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | In the course of screening for inhibitors of transforming-growth factor-beta (TGF-beta) functions we found that conophylline, a vinca alkaloid, inhibited TGF-beta-induced apoptosis in rat hepatoma cells. | conophylline | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | Because conophylline also inhibited TGF-b-induced promoter activity in mink lung cells, we studied the mechanism of the inhibition in this cell line. | conophylline | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | Thus, our data suggest that inhibition of TGF-beta-induced promoter activity by conophylline can be attributed to its potency in modulating the interaction of downstream transcriptional factors via upregulation of c-Jun expression. | conophylline | transforming growth factor, beta 1 | Rattus norvegicus |