Title : Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation.

Pub. Date : 2003 Nov 20

PMID : 14623117






2 Functional Relationships(s)
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1 In a cell-free system, the phosphorylation of glutathione S-transferase-fused c-Jun by recombinant JNK was not inhibited by dexamethasone but was inhibited by the addition of recombinant glucocorticoid receptor (GR). Dexamethasone mitogen-activated protein kinase 8 Rattus norvegicus
2 These findings suggest that the inhibition of antigen-induced IL-13 production by dexamethasone is due to the GR-mediated inhibition of c-Jun phosphorylation induced by JNK. Dexamethasone mitogen-activated protein kinase 8 Rattus norvegicus