Title : Role of NR2B-containing N-methyl-D-aspartate receptors in haloperidol-induced c-Fos expression in the striatum and nucleus accumbens.

Pub. Date : 2003

PMID : 14622917






2 Functional Relationships(s)
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1 Administration of haloperidol in rats leads to a robust induction of immediate-early genes including c-Fos throughout the striatum, which is significantly attenuated by pretreatment with the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801. N-Methylaspartate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 This suggests that NR2B-containing NMDA receptors are involved in mediating most of the NMDA-dependent c-Fos expression in the medial striatum, but only responsible for mediating part of this induction in the lateral striatum. N-Methylaspartate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus