Pub. Date : 2003
PMID : 14622917
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of NR2B-containing N-methyl-D-aspartate receptors in haloperidol-induced c-Fos expression in the striatum and nucleus accumbens. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Administration of haloperidol in rats leads to a robust induction of immediate-early genes including c-Fos throughout the striatum, which is significantly attenuated by pretreatment with the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Furthermore, to determine whether NMDA receptor subtype dependence of haloperidol-induced c-Fos expression is unique to the binding profile of haloperidol or whether it is a property of D2 receptor antagonism, the selective D2/D3 dopamine receptor antagonist, raclopride, was also used. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Furthermore, the pattern of attenuation of raclopride-induced c-Fos expression following Ro 25-6981 pretreatment was similar to that of haloperidol-induced c-Fos expression, indicating that the NMDA receptor subtype dependence of haloperidol-induced c-Fos expression is a property of D2 antagonism. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Furthermore, the pattern of attenuation of raclopride-induced c-Fos expression following Ro 25-6981 pretreatment was similar to that of haloperidol-induced c-Fos expression, indicating that the NMDA receptor subtype dependence of haloperidol-induced c-Fos expression is a property of D2 antagonism. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | The results indicate that NR2B-containing NMDA receptors are mainly involved in mediating haloperidol-induced c-Fos expression in the medial or "limbic" striatum, and suggest that NR2A-containing NMDA receptors may preferentially mediate haloperidol induced c-Fos expression in the lateral or "motor" striatum. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 7 | The results indicate that NR2B-containing NMDA receptors are mainly involved in mediating haloperidol-induced c-Fos expression in the medial or "limbic" striatum, and suggest that NR2A-containing NMDA receptors may preferentially mediate haloperidol induced c-Fos expression in the lateral or "motor" striatum. | Haloperidol | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |