Title : Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

Pub. Date : 2003 Nov 17

PMID : 14612912






3 Functional Relationships(s)
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1 Recently reported inhibitors of ABCG2 were evaluated and 50 microM novobiocin was found to reverse wild-type ABCG2 completely, but only reverse mutant ABCG2 partially. Novobiocin ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
2 Recently reported inhibitors of ABCG2 were evaluated and 50 microM novobiocin was found to reverse wild-type ABCG2 completely, but only reverse mutant ABCG2 partially. Novobiocin ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
3 Recently reported inhibitors of ABCG2 were evaluated and 50 microM novobiocin was found to reverse wild-type ABCG2 completely, but only reverse mutant ABCG2 partially. Novobiocin ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens