Title : Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.

Pub. Date : 2004 Jan

PMID : 14605879






1 Functional Relationships(s)
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1 Decreased phosphorylated-Akt by LY294002 treatment led to a down-regulation of Mcl-2 and phosphorylated Bad proteins, which are anti-apoptotic factors and belong to the Bcl-2 family. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one BCL2 apoptosis regulator Homo sapiens