Title : Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis.

Pub. Date : 2003

PMID : 14598883






2 Functional Relationships(s)
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1 Pretreatment of PD98059 decreased HGF-mediated phosphorylation of extracellular receptor kinase (ERK), uPA secretion and expression of matrix metalloproteinases (MMP-2 and MMP-9) in a dose-dependent manner. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one hepatocyte growth factor Homo sapiens
2 SB203580 also reversed the inhibition of HGF-mediated ERK activation and uPA secretion in the PD98059-pretreated cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one hepatocyte growth factor Homo sapiens