Pub. Date : 2003 Nov 15
PMID : 14598307
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plastic changes of calcitonin gene-related peptide in morphine tolerance: behavioral and immunohistochemical study in rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | The present study was undertaken to investigate the plasticity of calcitonin gene-related peptide (CGRP) in antinociception after morphine tolerance in rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | The present study was undertaken to investigate the plasticity of calcitonin gene-related peptide (CGRP) in antinociception after morphine tolerance in rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | Furthermore, there was an antinociceptive effect after intracerebroventricular injection of 2.5 nmol of CGRP in morphine-tolerant rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | Interestingly, the antinociceptive effect induced by intracerebroventricular injection of CGRP was lower in morphine-tolerant rats than that in opioid-naive rats at the same dose. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 6 | At the same time, there was downregulation of CGRP-like immunoreactivity in both lateral septal nucleus and central nucleus of amygdala tested by immunohistochemical methods, whereas no significant changes were observed in arcuate nucleus of hypothalamus and periaqueductal gray after morphine treatment in rats. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 7 | The present study demonstrates plastic changes in both CGRP-induced antinociception and CGRP-like immunoreactivity in rat brain after morphine tolerance, suggesting that CGRP may play an important role in morphine tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 8 | The present study demonstrates plastic changes in both CGRP-induced antinociception and CGRP-like immunoreactivity in rat brain after morphine tolerance, suggesting that CGRP may play an important role in morphine tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 9 | The present study demonstrates plastic changes in both CGRP-induced antinociception and CGRP-like immunoreactivity in rat brain after morphine tolerance, suggesting that CGRP may play an important role in morphine tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 10 | The present study demonstrates plastic changes in both CGRP-induced antinociception and CGRP-like immunoreactivity in rat brain after morphine tolerance, suggesting that CGRP may play an important role in morphine tolerance. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |