Title : Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression.

Pub. Date : 2003 Nov-Dec

PMID : 14592780






2 Functional Relationships(s)
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1 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Quinolinic Acid indoleamine 2,3-dioxygenase 1 Homo sapiens
2 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Quinolinic Acid indoleamine 2,3-dioxygenase 1 Homo sapiens