Pub. Date : 2003 Sep
PMID : 14582448
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Liver X receptor (LXR) alpha/beta nuclear receptors are intracellular sterol sensors that regulate expression of genes controlling cholesterol absorption, excretion, catabolism and cellular efflux in target organs, including small intestine, liver and macrophages. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | Through co-ordination of the expression of target genes in multiple tissues, LXR agonists increase the flux of cholesterol from the periphery to the liver, where it is metabolized and excreted into the bile. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |