Title : Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells.

Pub. Date : 2003 Oct 15

PMID : 14581377






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Apicidin induced the proteolytic cleavage of procaspase-9, -3, -8, and poly(ADP-ribose) polymerase. apicidin poly(ADP-ribose) polymerase 1 Homo sapiens
2 Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase. apicidin poly(ADP-ribose) polymerase 1 Homo sapiens