Pub. Date : 2003 Oct 15
PMID : 14581373
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Only CES2 gene expression correlated with the carboxylesterase activity assays (P < 0.01) with CPT-11 and 4-methylumbelliferyl acetate as substrates. | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 2 | CONCLUSIONS: We conclude that CES2 is the most abundant carboxylesterase in colon tumors that is responsible for CPT-11 hydrolysis. | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 3 | This pilot study reinforces the hypothesis that there is a large interindividual variation in expression of carboxylesterases that may contribute to variation in therapeutic outcome and/or toxicity of CPT-11 therapy for colon cancer. | Irinotecan | carboxylesterase 2 | Homo sapiens |