Pub. Date : 2003 Spring
PMID : 14566196
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paroxetine also has been shown to be a potent and selective inhibitor of the human serotonin transporter (SERT) and has recently been demonstrated to have moderate affinity for the norepinephrine transporter (NET). | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |
| 2 | Paroxetine also has been shown to be a potent and selective inhibitor of the human serotonin transporter (SERT) and has recently been demonstrated to have moderate affinity for the norepinephrine transporter (NET). | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |
| 3 | Paroxetine administration in laboratory animals has been shown to be associated with decreased SERT density and function, maintenance of normal firing rates and release of 5-HT, and increased activation of postsynaptic 5-HT receptors. | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |
| 4 | At usual clinical doses (ie, 20 mg/d), paroxetine is a potent and selective inhibitor of the SERT; however, at higher doses (ie, 40 mg/d), paroxetine can exhibit marked NET inhibition. | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |