Title : 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma.

Pub. Date : 2003 Oct

PMID : 14563954






3 Functional Relationships(s)
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1 These results suggest that the effect of 15d-PGJ(2) was through a PPARgamma-independent mechanism. 15d-pgj peroxisome proliferator activated receptor gamma Homo sapiens
2 In SK-Hep1 cells, the ability of 15d-PGJ(2) to induce cell toxicity, NF-kappaB suppression, or XIAP down-regulation seemed to occur via a PPARgamma-independent mechanism, but in HepG2 cells, NF-kappaB suppression by 15d-PGJ(2) was dependent on PPARgamma. 15d-pgj peroxisome proliferator activated receptor gamma Homo sapiens
3 In SK-Hep1 cells, the ability of 15d-PGJ(2) to induce cell toxicity, NF-kappaB suppression, or XIAP down-regulation seemed to occur via a PPARgamma-independent mechanism, but in HepG2 cells, NF-kappaB suppression by 15d-PGJ(2) was dependent on PPARgamma. 15d-pgj peroxisome proliferator activated receptor gamma Homo sapiens