Title : Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.

Pub. Date : 2003 Oct 16

PMID : 14562039

1 Functional Relationships(s)
Compound Name
Protein Name
1 In U937 cells, synergistic interactions between MG-132 and flavopiridol were associated with multiple perturbations in expression/activation of signaling- and survival-related proteins, including downregulation of XIAP and Mcl-1, activation of JNK and p34(cdc2), and diminished expression of p21(CIP1). alvocidib cyclin dependent kinase 1 Homo sapiens