Title : Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway.

Pub. Date : 2004 Feb

PMID : 14551058






2 Functional Relationships(s)
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1 These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)). SU 1498 Cbl proto-oncogene Homo sapiens
2 Furthermore, SU-1498 and Cbl(-nm) abolished the shear- and VEGF-induced Akt activity, indicating that Akt acts at a level downstream to Flk-1 and Cbl. SU 1498 Cbl proto-oncogene Homo sapiens