Title : Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.

Pub. Date : 2003 Nov

PMID : 14533013






1 Functional Relationships(s)
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1 The dose-dependent effect of a 24 h treatment with estradiol (E(2)) (1, 2, 5, 10 nM) and raloxifene (Rx) (1, 5, 10, 20 microM) on ER alpha and ER beta mRNA expression, collagen bio-synthesis, prolidase activity, MMP-2, MMP-9, insulin-like growth factor I receptor expression (IGF-1R) and beta1-integrin expressions in cultured fibroblasts obtained from postmenopausal women were examined. Raloxifene Hydrochloride estrogen receptor 2 Homo sapiens