Title : Natural product origins of Hsp90 inhibitors.

Pub. Date : 2003 Oct

PMID : 14529384






1 Functional Relationships(s)
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1 In the mid 1980s, it was found that the benzoquinone ansamycin antibiotics (herbimycin A, geldanamycin, and macbecin) reversed v-Src transformed cells to normal phenotypes, and Bcr-abl was subsequently suggested to be the molecular target for the treatment of chronic myelogenous leukemia through a study using herbimycin A for its selective antioncogenic activity. geldanamycin ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens