Title : Effect of thiamine on 3H-MPP+ uptake by Caco-2 cells.

Pub. Date : 2003 Dec

PMID : 14527822






3 Functional Relationships(s)
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1 The present study investigated a putative modulation of MPP+ intestinal apical uptake and ecto-ALP activity by thiamine (T+) and thiamine pyrophosphate (TPP, a T+ dietary precursor). Thiamine Pyrophosphate alkaline phosphatase, placental Homo sapiens
2 T+ and TPP were able to increase ecto-ALP activity, with an equal potency, and to decrease 3H-MPP+ apical uptake, with a similar potency. Thiamine Pyrophosphate alkaline phosphatase, placental Homo sapiens
3 The results suggest that the effect of T+ and TPP on ecto-ALP activity may lead to inhibition of the intestinal absorption of other organic cations present in the diet. Thiamine Pyrophosphate alkaline phosphatase, placental Homo sapiens