Title : Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.

Pub. Date : 2003 Oct

PMID : 14523042






1 Functional Relationships(s)
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1 Both the hyperglycemia-induced decrease in activity of GAPDH and its poly(ADP-ribosyl)ation were prevented by overexpression of either uncoupling protein-1 (UCP-1) or manganese superoxide dismutase (MnSOD), which decrease hyperglycemia-induced superoxide. Superoxides superoxide dismutase 2, mitochondrial Mus musculus