Title : Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).

Pub. Date : 2003 Oct 17

PMID : 14511769






2 Functional Relationships(s)
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1 FLAP stimulates bile flow up to 24% in control rats, but secretion is nearly absent in TR- rats further supporting an efficient transport of FLAP glucuronides by Mrp2. Glucuronides ATP binding cassette subfamily B member 4 Rattus norvegicus
2 In summary, we found that FLAP glucuronides are substrates of Mrp2 effectively inhibiting the biliary excretion of bilirubin. Glucuronides ATP binding cassette subfamily B member 4 Rattus norvegicus