Protein Name ATP binding cassette subfamily B member 4
Organism Rattus norvegicus
Gene ID 24891
Gene Symbol

Abcb4

UniProt Q08201 (MDR3_RAT)
Relationships Total Number of functionally related compound(s) : 120
Total Number of Articles : 101
Description

ATP binding cassette subfamily B member 4

Gene Summary

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in response to glucocorticoid and response to xenobiotic stimulus. Located in Golgi membrane and apical plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • phosphatidylcholine translocator ABCB4
  • ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
  • ATP-binding cassette sub-family B member 4
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Properties