Title : Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer.

Pub. Date : 2003 Nov 28

PMID : 14506281






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1 These data suggest that apoptosis induced by sulindac sulfone is mediated, in part, by the COX-independent, PPAR-dependent transcriptional activation of SSAT, leading to reduced tissue polyamine contents in human colon cancer cells. sulindac sulfone peroxisome proliferator activated receptor alpha Homo sapiens