Title : Pentoxifylline inhibits platelet-derived growth factor-stimulated cyclin D1 expression in mesangial cells by blocking Akt membrane translocation.

Pub. Date : 2003 Oct

PMID : 14500737






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The PKA antagonist N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline (H89) abolishes cell proliferation effects of PTX and restores cyclin D1 expression as well as Akt membrane translocation and activation by PDGF, whereas dibutyryl cAMP and forskolin recapitulate the functions of PTX in mesangial cells. n-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus