Title : Improved insulin stability through amino acid substitution.

Pub. Date : 1992 Sep

PMID : 1438162






3 Functional Relationships(s)
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Protein Name
Organism
1 The maintenance of the native state of insulin was shown to be important in protecting the disulfides from reduction by dithiothreitol and implicitly from the disulfide interchange reaction that occurs during storage. Disulfides insulin Homo sapiens
2 The maintenance of the native state of insulin was shown to be important in protecting the disulfides from reduction by dithiothreitol and implicitly from the disulfide interchange reaction that occurs during storage. Disulfides insulin Homo sapiens
3 A significant positive correlation (R2 = 0.8 and P less than 0.0005) exists between the conformational stability and chemical stability of these analogs, indicating that the chemical stability of insulin"s disulfides is under the thermodynamic control of the conformational equilibria. Disulfides insulin Homo sapiens