Pub. Date : 1992 Nov
PMID : 1432691
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present studies describe the behavioral responses of three strains of mice carrying one of two mutations in the HPRT gene to agents which interact with brain dopamine systems. | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |
| 2 | HPRT- mice are more sensitive than age- and sex-matched littermates to the motor-activating properties of dopamine-releasing agents (amphetamine, amfonelic acid and methylphenidate), but not dopamine uptake inhibitors (GBR 12909 and nomifensine). | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |
| 3 | The enhanced sensitivity of the HPRT- mice to the dopamine-releasing agents is not caused by dopamine receptor supersensitivity, because the HPRT- mice do not show enhanced motor responses to the direct D1/D2 dopamine receptor agonist apomorphine or to the selective D1 dopamine receptor agonist SKF 38393. | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |
| 4 | The enhanced sensitivity of the HPRT- mice to the dopamine-releasing agents is not caused by dopamine receptor supersensitivity, because the HPRT- mice do not show enhanced motor responses to the direct D1/D2 dopamine receptor agonist apomorphine or to the selective D1 dopamine receptor agonist SKF 38393. | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |
| 5 | Biochemical analysis shows that the HPRT- mice have significantly lower levels of dopamine (-45%), but normal levels of tyrosine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 3-methoxytyramine in the caudoputamen. | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |
| 6 | These results indicate the existence of an inherent abnormality in the dopamine systems in the brains of HPRT- mice, despite their apparently normal spontaneous behavior. | Dopamine | hypoxanthine guanine phosphoribosyl transferase | Mus musculus |