Title : Defects in type IIA von Willebrand disease: a cysteine 509 to arginine substitution in the mature von Willebrand factor disrupts a disulphide loop involved in the interaction with platelet glycoprotein Ib-IX.

Pub. Date : 1992 Sep

PMID : 1419804






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Defects in type IIA von Willebrand disease: a cysteine 509 to arginine substitution in the mature von Willebrand factor disrupts a disulphide loop involved in the interaction with platelet glycoprotein Ib-IX. disulphide von Willebrand factor Homo sapiens
2 The Cys 509-->Arg substitution eliminates an intramolecular disulphide bridge formed by Cys 509 and Cys 695 which is important to maintain the configuration of vWF functional domains that interact with platelet glycoprotein Ib-IX. disulphide von Willebrand factor Homo sapiens